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Psychedelic Definition & Meaning Sorted populations were processed for RNA extraction and subjected to quantitative RT-PCR for gene expression analysis. Only about 3% of total mPFC cells were activated in response to DOI; after identification, it was found that these activated cells displayed a 10-fold higher expression of 5-HT2A receptors than the nonactivated population. The highest 5-HT2A receptor expression and cellular activation was seen in these cells, which were identified as claustral cells, in which nearly Psychedelic one-half of the neurons were directly activated by DOI. Pazos et al. examined 5-HT2 receptor distribution in the human brain using light microscopic autoradiography with the 5-HT2A antagonist ligand ketanserin. A heterogeneous distribution of 5-HT2 receptor densities was observed, with high expression localized over layers III and V of several cortical areas, including the frontal, parietal, temporal, and occipital lobes, the anterogenual cortex, and the